Scribe Therapeutics is a molecular engineering company focused on creating best-in-class in vivo therapies that permanently treat the underlying cause of disease. Founded by CRISPR inventors and leading molecular engineers Benjamin Oakes, Brett Staahl, David Savage, and Jennifer Doudna, Scribe is overcoming the limitations of current genome editing technologies by developing custom engineered enzymes and delivery modalities as part of a proprietary, evergreen CRISPR by Design™ platform for CRISPR-based genetic medicine.
We are seeking a highly creative, passionate, and motivated individual to join us in our quest to develop the next generation of CRISPR-based therapeutics. The current role is for a Scientist I position on the Genotoxicity team to help us develop and execute off-target assays to profile the safety of our gene editing platforms. The candidate should have a passion for working collaboratively with biologists, protein engineers, and bioinformaticians. Additionally, the candidate would bring expertise in next-generation sequencing, molecular biology, and cell culture techniques to develop assays to detect on- and off-target editing outcomes and shape the next generation of therapeutic gene editors.
The candidate will have numerous opportunities for professional growth in a rapidly growing biotechnology start-up, which includes growing into a leadership role of increasing responsibilities and the ability to publish highly impactful work in peer reviewed journals.
Key Responsibilities:
- Work closely with Scribe’s teams to develop and execute assays to assess the off-target activity of CRISPR-based therapies across a range of enzymes, targets, and delivery systems
- Collaborate across pre-clinical therapeutic groups both within the company and externally to drive rapid advancement of new targets and molecules
- Ensure high quality data generation through proper assay validation and qualification
- Assume project responsibilities and effectively present updates, and communicate research plans and timelines to the senior leadership team internally and partners externally
- Critically evaluate experimental data and communicate scientific findings as verbal presentations and written reports
- Foster a driven, fast-paced, dynamic, and fun environment in which to do rigorous science
Required Skills and Background:
- PhD in molecular biology, cell biology, genetics, bioengineering or related field. A postdoc and/or 1+ years industry experience is a plus
- Experience with a range of assay development in next-generation sequencing techniques, including both library preparation and data analysis
- Depth of experience with mammalian tissue culture techniques
- Experience in Python programming, unix command line, version control systems (e.g. git), bioinformatic and computational biology toolkits applied to NGS analysis
- Ability to work collaboratively in a fast-paced, interdisciplinary research team
- Excellent prioritization and organization skills
Preferred Skills and Background:
- Experience with CRISPR-Cas gene editing systems and delivery technology
- Background in DNA repair/DNA damage response pathways
- Familiarity with current methods of on-target, off-target editing assessments
- Track record of methods development and innovation
Salary will be commensurate with experience. We will provide an intellectually stimulating, collegial and fast-paced environment. If you are ready to engineer the future of therapeutics, then we are excited to hear from you! Visit us at www.scribetx.com.
We are committed to creating a diverse environment and are proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, disability, age, or veteran status.
At the time of posting, the base pay wage range for this role is $110,000-130,000 per year. The offered pay range will depend on internal equity and the candidate’s relevant skills, experience, qualifications, training, and market data. Additional incentives are provided as part of the complete package in addition to comprehensive medical and other benefits.
